Modular approach – to meet your specific needs
CellTool develops various analytical platforms tailored to different applications in biomedical research and clinical diagnostics. All of them comprise as basic components a high-end microscope, a Raman laser, elements for laser-beam guidance, a spectrograph for signal detection and a PC or Mac for automated system control. The platforms differ in terms of add-on modules, sample mount and software, which are adapted to the respective application.
For each system, CellTool also supplies the required consumables, e.g. tailored microfluidic slides, Raman-compatible petri dishes or sample preparation kits for certain probes.
Raman spectroscopy for living cells
BioRam, CellTool’s most advanced analytical platform, is available for customers.
Adapted to living samples – BioRam comprises all the basic components (see overview), together with a temperature-controlled and contamination-proof chamber for living biological samples and specific software for system control and data analysis. The basic version can be upgraded with microfluidics for increased throughput and contact-free sorting of cells. BioRam allows verification of spectroscopic results comparing them with conventional fluorescence measurements.
The measurement process: Just get going
Samples can be used without special preparation: as living tissue, in aqueous solution on Raman-compatible slides or directly in culture medium in Raman-compatible petri dishes or fluidic chips. With a 3D-mouse, you can home in on the cells to be analysed and start the automatic generation of Raman spectra with a mouse click. Cells are then automatically identified according to their spectra by database comparison. Measurement coordinates, live images, raw data and all the relevant parameters are saved as well, enabling further analysis or the application of alternative algorithms at any time.
The opportunities: Take the decisive next step in your work
Identify cell types and activity states without labelling and under physiological conditions
Distinguish cells that cannot clearly be differentiated based on markers
Determine stem cell types and their differentiation stages
Spot very rare cells in clinical samples
Differentiate cancerous from healthy cells
Investigate cell–cell and cell–small molecule interactions live
Monitor cellular processes in cell or tissue cultures over longer times online
Preserve cell viability and use unaltered cells for downstream applications
Work with minimal sample volumes
Compare and verify with fluorescence
Various application specific inserts are available
Browse also the overview of advantages